Akteursbasierte Simulation der energetischen Modernisierung des Wohngebäudebestands in Deutschland

In diesem Buch wird das akteursbasierte Wohngebäude- und Haushaltsmodell AWOHM zur Identifizierung und Konzipierung adäquater Bündel umweltpolitischer Instrumente im Themenfeld Wärmenutzung mit Fokus auf der energetischen Modernisierung entwickelt und auf die Bundesrepublik Deutschland angewandt. Dabei werden umweltpolitische Instrumentenbündel zusammengestellt, die an die Charakteristika der Gebäude, Eigentümer und Bewohner angepasst sind

Building Information Modeling (BIM) for existing buildings - literature review and future needs

Abstract not availableRebekka Volk, Julian Stengel, Frank Schultman

Neurofascin-155 IgM autoantibodies in patients with inflammatory neuropathies

Objectives Recently, IgG autoantibodies against different paranodal proteins have been detected and this has led to important advances in the management of inflammatory neuropathies. In contrast, not much is known on IgM autoantibodies against paranodal proteins. Methods In the present study, we screened a large cohort of patients (n=140) with inflammatory neuropathies for IgM autoantibodies against neurofascin-155, neurofascin-186 or contactin-1. Results IgM autoantibodies against neurofascin-155 were detected by ELISA in five patients, four with inflammatory demyelinating polyradiculoneuropathy (CIDP) and one with Guillain-Barre syndrome (GBS), and were confirmed by ELISA-based preabsorption experiments and Western blot. Titres ranged from 1:100 to 1:400. We did not detect IgM anti-neurofascin-186 or anti-contactin-1 antibodies in this cohort. All patients presented with distally accentuated tetraparesis and hypesthesia. Remarkably, tremor was present in three of the patients with CIDP and occurred in the patients with GBS after the acute phase of disease. Nerve conduction studies revealed prolonged distal motor latencies and F wave latencies. Nerve biopsies showed signs of secondary axonal damage in three of the patients, demyelinating features in one patient. Teased fibre preparations did not demonstrate paranodal damage. Conclusion In summary, IgM neurofascin-155 autoantibodies may be worth testing in patients with inflammatory neuropathies. Their pathogenic role needs to be determined in future experiments

ISA: Immissionsschutz beim Abbruch - Minimierung von Umweltbelastungen (Lärm, Staub, Erschütterungen) beim Abbruch von Hoch-/Tiefbauten und Schaffung hochwertiger Recyclingmöglichkeiten für Materialien aus Gebäudeabbruch

Folgende drei Instrumente wurden entwickelt, mit deren Hilfe der Immissionsschutz zukünftig in die Planung und Durchführung von Abbruch- und Rückbauvorhaben integriert werden kann: eine Datenbank mit ökonomischen, ökologischen und technischen Kennwerten für die Planung des Abbruch- und Rückbauprozesses, ein auf die Datenbank zurückgreifender Prototyp eines IT-gestützten Planungsunterwerkzeuges, der an realen Rückbau- und Abbruchprojekten getestet wurde, ein prototypisches Immissionserfassungssystem zur permanenten Immissionsüberwachung

National Integrated Assessment Modelling zur Bewertung umweltpolitischer Instrumente : Entwicklung des otello-Modellsystems und dessen Anwendung auf die Bundesrepublik Deutschland

Auf internationaler Ebene wurden Ziele zur Minderung von Luftschadstoff- und klimarelevanten Emissionen vereinbart, deren Umsetzung den jeweiligen Unterzeichnerstaaten obliegt. Hierzu existieren zahlreiche umweltpolitische Instrumente, deren Effektivität und Effizienz jedoch schwer abschätzbar sind. Daher ist es das Anliegen des im vorliegenden Buch beschriebenen otello-Modellsystems, solche politischen Instrumente in ihren ökologischen und ökonomischen Wirkungsmechanismen zu bewerten

Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death

Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis Complex 1 (TSC1) and TSC2 play a fundamental role in cell homeostasis, where signal transduction through TSC1/TSC2 is often compromised in cancer, leading to aberrant activation of mechanistic target of rapamycin complex 1 (mTORC1). mTORC1 hyperactivation increases the basal level of endoplasmic reticulum (ER) stress via an accumulation of unfolded protein, due to heightened de novo protein translation and repression of autophagy. We exploit this intrinsic vulnerability of tumor cells lacking TSC2, by treating with nelvinavir to further enhance ER stress while inhibiting the proteasome with bortezomib to prevent effective protein removal. We show that TSC2-deficient cells are highly dependent on the proteosomal degradation pathway for survival. Combined treatment with nelfinavir and bortezomib at clinically relevant drug concentrations show synergy in selectively killing TSC2-deficient cells with limited toxicity in control cells. This drug combination inhibited tumor formation in xenograft mouse models and patient-derived cell models of TSC and caused tumor spheroid death in 3D culture. Importantly, 3D culture assays differentiated between the cytostatic effects of the mTORC1 inhibitor, rapamycin, and the cytotoxic effects of the nelfinavir/bortezomib combination. Through RNA sequencing, we determined that nelfinavir and bortezomib tip the balance of ER protein homeostasis of the already ER-stressed TSC2-deficient cells in favor of cell death. These findings have clinical relevance in stratified medicine to treat tumors that have compromised signaling through TSC and are inflexible in their capacity to restore ER homeostasis

Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis

Peer reviewe

Ramipril and Risk of Hyperkalemia in Chronic Hemodialysis Patients

Angiotensin converting enzyme (ACE) inhibitors provide well known cardiorenal-protective benefits added to antihypertensive effects in chronic renal disease. These agents are underused in management of patients receiving hemodialysis (HD) because of common concern of hyperkalemia. However, few studies have investigated effect of renin angiotensin aldosterone system (RAAS) blockade on serum potassium in hemodialysis patients. We assessed the safety of ramipril in patients on maintenance HD. We enrolled 28 adult end stage renal disease (ESRD) patients treated by maintenance HD and prescribed them ramipril in doses of 1.25 to 5 mg per day. They underwent serum potassium concentration measurements before ramipril introduction and in 1 to 3 months afterwards. No significant increase in kalemia was found. Results of our study encourage the use of ACE inhibitors in chronically hemodialyzed patients, but close potassium monitoring is mandatory